网易未来大会未来科技人物候选人鲁白
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5. K. Sakata K. Martinowich, N. H. Woo, D. V. Jimenez, R. Schlosser, Y. Ji., L. Shen, B. Lu Role of activity-dependent BDNF expression in hippocampal-prefrontal cortical regulation of behavioral perseverance. Proc. Natl. Acad. Sci. USA. 110:15103-15118. 2013. Significant paper, revealed that activity-dependent BDNF expression is critical for behavioral flexibility. 6. H. –S. Je, S. Portruli, F. Yang, H. –S. Je, , S. Portruli, Y. Ji, G. Nagappan, B. Hempstead, Y. Son, and B. Lu Role of proBDNF to mature BDNF conversion in activity-dependent competition at developing neuromuscular synapses. Proc. Natl. Acad. Sci. USA. 109, 15924-15929. 2012 Significant paper, revealed a molecular mechanism underlying activity-dependent synaptic competition, a central issue in developmental neurobiology. 7. B. Fischer, J. Reis, K. Martinowich, H. M. Schambra, Y. Ji, L. Cohen, B. Lu DC Stimulation-Enhanced Motor Learning Is Mediated by BDNF-dependent Long-term Synaptic Potentiation. Neuron 66, 198-204. 2010. Significant paper, demonstrated a way to manipulate BDNF secretion in human brain in vivo. 8. Y. Ji, Y. Lu, L. Feng, T. T. Tang, B. Lu Acute and gradual increases in BDNF concentration elicit very different signaling events and cellular responses in hippocampal neurons. Nature Neuroscience 13, 302-309, 2010. Significant paper, demonstrated that a single extracellular factor could induce distinct signaling and functions based on how it is delivered. 9. K. Sakata, N. H. Woo, K. Martinowich, J. S. Greene, R. Schlosser, L. Shen, B. Lu Critical role f promoter-IV-driven BDNF transcription in GABAergic transmission and synaptic plasticity in the prefrontal cortex, Pro. Natl. Acad. Sci. 106, 5942–5947, 2009. Significant paper, discovered a role of activity-dependent BDNF expression in synaptic modulation distinct from basal BDNF expression. 10. N. H. Woo, C. J. Siao P. T. Pang, H. K. Teng, T. A.Milner, B. L. Hempstead, B. Lu ProBDNF/p75NTR signaling is necessary for hippocampal long-term depression. Nature Neuroscience 8, 1069-1077, 2005. Significant paper, discovered the role of ProBDNF p75NTR signaling in synaptic plasticity, formed the basis for “Yin and Yang Hypothesis of Neurotrophin”. 11. P. T. Pang, H. K. Teng, N. Woo, E. Zaitsev, K. Sakata, S. Zhen, K. K. Teng, W.-H. Yung, B. L. Hempstead, B. Lu Cleavage of ProBDNF by the tPA/plasmin is essential for long-term hippocampal plasticity, Science 306, 487-491, 2004. Significant paper, discovered the extracellular protease cleavage of proBDNF in the brain, and the role proBDNF to mature BDNF conversion in long-term synaptic plasticity. 12. M. F. Egan, M. Kojima, J. H. Callicott, T. E. Goldberg, B. S. Kolachana, E. Zaistev, A. Bertolino, B. Gold, D. Goldman, M. Dean, B. Lu, (co-corresponding author) and D. R. Weinberger A single nucleotide polymorphism in BDNF gene affects regulated secretion of BDNF and human memory and hippocampal function, Cell 112, 257-269, 2003. Seminal paper, provided the first link between a human genetic polymorphism and cellular and cognitive function. Selected by Science as No. 2 in “10 Breakthrough of the Year”. 13. A. Figurov, L. Pozzo-Miller, T. Wang, P. Olafsson, B. Lu Regulation of synaptic responses to high-frequency stimulation and LTP by neurotrophins in the hippocampus, Nature 381, 706-709, 1996. Seminal paper, viewed as pioneering study of neurotrophin regulation of synaptic plasticity. 14. T. Wang, K. Xie, and B. Lu Neurotrophins promote maturation of developing neuromuscular synapses. J. Neurosci. 15, 4796-4805, 1995. Significant paper, first report of long-term regulation of synapses by neurotrophins. 15. H. G. Kim, T. Wang, P. Olafsson, and B. Lu Neurotrophin-3 potentiates neuronal excitability and inhibits g-aminobutyratergic synaptic transmission in cortical neurons, Proc. Natl. Acad. Sci. USA 91, 12341-12345, 1994. Significant paper, first demonstration of acute effects of a neurotrophin on CNS neurons and synapses. 重要的综述(共35篇已发表) 1. B. Lu, G. Nagappan, X. Guan, and P. Wren (2013) BDNF-based synaptic repair as a disease-modifying strategy for neurodegenerative diseases. Nature Review Neuroscience. 14, 401-416. （编辑：171手机网） 【声明】本站内容均来自网络，其相关言论仅代表作者个人观点，不代表本站立场。若无意侵犯到您的权利，请及时与联系站长删除相关内容! |
